Despair

·vt To cause to despair.

II. Despair ·noun That which is despaired of.

III. Despair ·noun Loss of hope; utter hopelessness; complete despondency.

IV. Despair ·vt To give up as beyond hope or expectation; to despair of.

V. Despair ·vi To be hopeless; to have no hope; to give up all hope or expectation;

— often with of.