·noun Malice; malignity; spite; malicious anger; contemptuous hate.
II. Despite ·noun An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
III. Despite ·noun To Vex; to Annoy; to offend contemptuously.
IV. Despite ·prep In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.