- Sheppy Yard
- Sherborne Lane
- Sheremonier's Lane
- Sheriffs
- The Ship
- Ship Alley
- Ship Court
- Ship Court, Bartholomew Lane
- Ship Tavern
- Ship Tavern Passage
- Ship Yard
- Ship Yard, Minories
- Shippey's Yard
- Shipwrights
- Shirbourne Lane
- Shire Lane
- Shiryngton Chapel
- Shitteborwelane
- Shiteburuelane
- Shiteburghiane
- Shoe Lane
- Shoemaker Row, Lane
- Shoemaker's Row
- Shoemakers' Row, West Smithfield
- Shof Lane
- Sholand
- Shooler's Court
- Shooters Court
- Shopereslane
- Short Street
- Shorter Street
- Shorters Court
- Shovel Alley, St. Katherlne's
- Shovel Court
- Showe Lane
- Showell
- Shrewsbury Court
- The Shrouds
- Shunamites' House
- Shusshestrate
- Shuter's Court
- Shute's Court
- Shutter's Court
- Shyte Burnes Lane
- Shyvethenestrat
- The Sieve
- Silk Street
- Silk Throwers
- Silkmen
- Silver Street
- Silver Street, Bouverie Street
- Silver Street, Bridgewater Square
- Simpson Lane
- Sion College
- Sion Court
- Sir George Waterman's House
- Sir Henry Tulce's House
- Sir John Cass' School
- Sir John Fouches
- Sir John Hubland's
- Sir John Lawrence's House
- Sir Joseph Sheldon's House
- Sir Nathaniel Herne's House
- Sir Patient Ward's House
- Sir Richard Levet's House
- Sir Robert Clayton's House
- Sir Robert Vyner's House
- Sir Samuel Barnardiston's House
- Sir Thomas Bludworth's House
- Sir Thomas Davis' House
- Sise Lane
- Sithebourne Lane
- (St.) Sithes
- (St.) Sithes Lane
- Siuendestret or Lane, Sivende Lane
- Six Bell Alley
- Six Bell Court
- Six Bell Passage
- Six Clerks' Office
- Six Garden Court, Paul's Alley, Cripplegate
- Six Penny Receivers' Office
- Size Lane
- Le Skaldynghouse
- Skales Inn
- Skimmer's Alley
- Skinner Street
- Skinner Street Passage
- Skinner Street, Bishopsgate
- Skinner's Alley
- Skinner's Alley, Houndsditch
- Skinners' Company
- Skinners' Hall
- Skinners' Place
- Skinners' Rents, Bishopsgate
- Skinnersshoppe
- The Skomer
- Skuttes Key
- Slade's Buildings
- Slaper's [Sloper's?] Lane
- Sloperlane