- Slade's Buildings
- Slaper's [Sloper's?] Lane
- Sloperlane
- Smale Lane
- Small Alley
- Smart's Key
- Smethe Lane
- Smethefeld
- Smethfeld del Barbican
- Smither's Coffee House
- Smither's Lane
- Smithfield
- Smithfield, East
- Smithfield Market
- Smithfield Penns
- Smith's Almshouses
- Smith's Buildings
- Smith's Buildings, Billiter Street
- Smith's Court
- Smith's Rents
- Smith's Wharf
- Smith's Yard
- Smlthfield Bars
- Smyth Lane
- Smythes Lane
- Sneaking Alley
- Snow Hill
- Snuff Yard, Houndsditch
- Soaper's Alley, Bishopsgate Without
- Soaper's Yard, St, Mary Axe
- Socage
- Socnere
- Soke
- Soldiers' Court, Grub Street, Cripplegate
- Somar's Key
- Somer's Key Gateway
- Somer's Quay Stairs
- Somerset Buildings
- Somerset Court
- Somerset Inn
- Somerset Street
- Sommer's Key
- Sondaye Wharf
- Sondayes Alley
- Sopemakers
- Soper's Lane
- Soper's Lane, Porters of
- Soper's Yard
- Sopporlane
- Soukinge Lane
- Souldier's Court
- South Alley
- South Place
- South Place Mews
- South Sea Chambers
- South Sea Court
- South Sea House
- South Sea Passage
- South Sea Yard
- Southam Lane
- Southampton House
- Southgate
- Southwark Bridge
- Southwark Bridge Stairs
- (Lord) Sowches' House
- Spanish Ambassador's House
- Spanish and Portuguese Synagogue, Bevis Marks
- Spark's Place
- Sparrow Corner
- Spectacle Alley
- Spectacle Makers
- Spectacle's Alley
- Spectacle's Rents
- The Spicery In Westcheap
- Spinning Wheel Alley
- Spital Bar
- Spital Ditch
- Spital House
- Spital Square
- Spital Yard
- Spitalfields
- Spitel Lane, Vintry
- Spittlefields
- Spooner's Lane
- Sporenereslane
- Sporiar Lane, Sporiereslane
- Sporier's Inn
- Sporierstret
- Sporones Lane
- Sporyer Row
- Spread Eagle Court
- Spread Eagle Inn and Yard
- Sprinckle Alley
- Spuren Lane
- Le Spurrers' House
- Spurrier Lane
- Spurrier Row
- Spytell Wharf
- Squerell Alley, Minories
- Squire Alley, Squirel's Alley, Minories