- The Sieve
- Silk Street
- Silk Throwers
- Silkmen
- Silver Street
- Silver Street, Bouverie Street
- Silver Street, Bridgewater Square
- Simpson Lane
- Sion College
- Sion Court
- Sir George Waterman's House
- Sir Henry Tulce's House
- Sir John Cass' School
- Sir John Fouches
- Sir John Hubland's
- Sir John Lawrence's House
- Sir Joseph Sheldon's House
- Sir Nathaniel Herne's House
- Sir Patient Ward's House
- Sir Richard Levet's House
- Sir Robert Clayton's House
- Sir Robert Vyner's House
- Sir Samuel Barnardiston's House
- Sir Thomas Bludworth's House
- Sir Thomas Davis' House
- Sise Lane
- Sithebourne Lane
- (St.) Sithes
- (St.) Sithes Lane
- Siuendestret or Lane, Sivende Lane
- Six Bell Alley
- Six Bell Court
- Six Bell Passage
- Six Clerks' Office
- Six Garden Court, Paul's Alley, Cripplegate
- Six Penny Receivers' Office
- Size Lane
- Le Skaldynghouse
- Skales Inn
- Skimmer's Alley
- Skinner Street
- Skinner Street Passage
- Skinner Street, Bishopsgate
- Skinner's Alley
- Skinner's Alley, Houndsditch
- Skinners' Company
- Skinners' Hall
- Skinners' Place
- Skinners' Rents, Bishopsgate
- Skinnersshoppe
- The Skomer
- Skuttes Key
- Slade's Buildings
- Slaper's [Sloper's?] Lane
- Sloperlane
- Smale Lane
- Small Alley
- Smart's Key
- Smethe Lane
- Smethefeld
- Smethfeld del Barbican
- Smither's Coffee House
- Smither's Lane
- Smithfield
- Smithfield, East
- Smithfield Market
- Smithfield Penns
- Smith's Almshouses
- Smith's Buildings
- Smith's Buildings, Billiter Street
- Smith's Court
- Smith's Rents
- Smith's Wharf
- Smith's Yard
- Smlthfield Bars
- Smyth Lane
- Smythes Lane
- Sneaking Alley
- Snow Hill
- Snuff Yard, Houndsditch
- Soaper's Alley, Bishopsgate Without
- Soaper's Yard, St, Mary Axe
- Socage
- Socnere
- Soke
- Soldiers' Court, Grub Street, Cripplegate
- Somar's Key
- Somer's Key Gateway
- Somer's Quay Stairs
- Somerset Buildings
- Somerset Court
- Somerset Inn
- Somerset Street
- Sommer's Key
- Sondaye Wharf
- Sondayes Alley
- Sopemakers
- Soper's Lane
- Soper's Lane, Porters of
- Soper's Yard