- Spanish Ambassador's House
- Spanish and Portuguese Synagogue, Bevis Marks
- Spark's Place
- Sparrow Corner
- Spectacle Alley
- Spectacle Makers
- Spectacle's Alley
- Spectacle's Rents
- The Spicery In Westcheap
- Spinning Wheel Alley
- Spital Bar
- Spital Ditch
- Spital House
- Spital Square
- Spital Yard
- Spitalfields
- Spitel Lane, Vintry
- Spittlefields
- Spooner's Lane
- Sporenereslane
- Sporiar Lane, Sporiereslane
- Sporier's Inn
- Sporierstret
- Sporones Lane
- Sporyer Row
- Spread Eagle Court
- Spread Eagle Inn and Yard
- Sprinckle Alley
- Spuren Lane
- Le Spurrers' House
- Spurrier Lane
- Spurrier Row
- Spytell Wharf
- Squerell Alley, Minories
- Squire Alley, Squirel's Alley, Minories
- Squirrel Alley
- St. John's Court, Somerset Street
- Stable Yard
- Stable Yard, Baker's Buildings
- Stable Yard, Berry Street
- Stable Yard, Church Lane
- Stable Yard, Cutler Street
- Stable Yard, Hand Alley
- Stable Yard, Poor Jewry Lane
- Stable Yard, Woodroff Lane
- Staining Lane
- Staining Lane Church
- Stalhof
- Stamford Inn
- Standard
- The Standard in Fleet Street
- Standard in Cornhill
- Standard in the Old Bailey
- Standard in Westcheap
- Stanene Chirche
- Stanigg Cherche
- Stanning Chirche
- Staningelane
- Stanns Alley
- Stanyng
- La Stapeledehall
- Staple Hall
- Staple Hall, Barking Church
- Staple Inn
- The Star
- Star Alley
- Star Alley, Mark Lane
- Star Alley, Seething Lane
- Star Court
- Star Court, Houndsditch
- Star Court, Minories
- Star Court, Nightingale Lane
- Star Inn
- Star Yard
- Star Yard, Huggin Lane
- Star Yard, Petty France
- Starling School
- Starr Alley
- Stationers' Alley
- Stationers' Company
- Stationers' Court
- Stationers' Hall
- Stationers' Hall Buildings
- Stationers' Hall Court
- Stationers' House
- Stationers' Rents
- Stationers' School
- Statue of King William IV
- Statue of Queen Anne
- Steel Alley
- Steel's Court
- Steel's Yard
- The Steelyard
- Steelyard Lane
- Steelyard Stairs
- Steelyard Wharf
- Steer's Place
- (St.) Stephen Coleman Street
- (St.) Stephen in the Jewry
- (St.) Stephen Walbrook